Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314
نویسندگان
چکیده
منابع مشابه
The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats
BACKGROUND The lidocaine derivative, QX-314, produces long-lasting regional anesthesia in various animal models. We designed this study to examine whether QX-314 could produce long-lasting intravenous regional anesthesia (IVRA) in a rat model. METHODS IVRA was performed on tail of rats. EC50 (median effective concentration) of QX-314 in IVRA was determined by up-and-down method. IVRA on tail ...
متن کاملPermeation and block of TRPV 1 channels by the cationic lidocaine derivative QX - 314 1 2 3 4
37 QX-314 (N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage38 dependent sodium channels when applied internally to axons or neuronal cell bodies. Co39 application of external QX-314 together with the TRPV1 agonist capsaicin produces 40 long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX41 314 entry into the neurons. We asked whether QX-3...
متن کاملProlonged sensory-selective nerve blockade.
Sensory-selective local anesthesia has long been a key goal in local anesthetic development. For example, it allows women to be pain-free during labor without compromising their ability to push. Here we show that prolonged sensory-selective nerve block can be produced by specific concentrations of surfactants-such as are used to enhance drug flux across skin-in combination with QX-314, a lidoca...
متن کاملQuaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.
BACKGROUND The relatively membrane-impermeable lidocaine derivative QX-314 has been reported to permeate the ion channels transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) to induce a selective inhibition of sensory neurons. This approach is effective in rodents, but it also seems to be associated with neurotoxicity. ...
متن کاملCoapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.
BACKGROUND Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314-mediated block would limit clinical utility. Because TRPV1 channels are also ...
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ژورنال
عنوان ژورنال: Translational Vision Science & Technology
سال: 2019
ISSN: 2164-2591
DOI: 10.1167/tvst.8.5.28